Recension
CHAPTER 1
The child, child health, pediatrics and child healthcare in contemporary society – D Kalaikov
CHAPTER 2
Immunizations in children – D Kalaikov
CHAPTER 3
Growth and development – Е Stefanova
Neuropsychic development (NPD) – I Litvinenko
CHAPTER 4
Nutrition of children – P Yaneva, D Kofinova
CHAPTER 5
Fluid and electrolytes and acid-base abnormalities in childhood – D Iliev
CHAPTER 6
Principles of therapy in childhood – D Konstantinov
CHAPTER 7
Clinical genetics
Chromosomal disorders – R Tincheva
Down syndrome
Trisomy
Trisomy
Turner syndrome
Klinefelter syndrome
Microdeletion syndromes – D Avdjieva-Tzavella
Genetic counseling – D Avdjieva-Tzavella
Inborn errors of metabolism
Inborn errors of metabolism – an overview – D Avdjieva-Tzavella
Disorders of amino acid metabolism – H Kathom
Phenylketonuria
Urea cycle disorders
Tyrosinemia
Propionic acidemia
Methylmalonic acidemia
Maple syrup urine disease – leucinosis96
Galactosemia – D Avdjieva-Tzavella
Glycogenoses – D Avdjieva-Tzavella
Fatty acid oxidation disorders – D Avdjieva-Tzavella
Mitochondrial disorders – D Avdjieva-Tzavella
Lysosomal storage disease – R Tincheva
Mucopolysaccharidoses
Gaucher disease
Niemann–Pick disease
Fabry disease
GM1 Gangliosidosis
GM2 Gangliosidosis
Krabbe disease
Metachromatic leukodystrophy
Peroxisomal disorders – D Avdjieva-Tzavella
Zellweger spectrum 110
X-linked adrenoleukodystrophy
CHAPTER 8
Neonatology
Risk births – R Gueorguieva
Respiratory disorders in neonatal period – R Gueorguieva
Respiratory distress syndrome in preterm infants
Respiratory distress syndrome in term infants
Other causes of respiratory distress syndrome
Respiratory tract abnormalities
Bronchopulmonary dysplasia
Neonatal infections – D Vlahova
Neonatal jaundice – D Vlahova
Perinatal injuries of central nervous system in neonatal period – R Gueorguieva
Intracranial haemorrhages
Ischemic injury of CNS
Neonatal seizures
CHAPTER 9
Rheumatology
Juvenile idiopathic arthritis – S Stefanov, M Ganeva
Acute rheumatic fever – A Telcharova-Mihaylovska, K Temelkova
Reactive arthritis – S Stefanov, K Temelkova
Systemic lupus erythematosus – A Telcharova-Mihaylovska, M Ganeva
Juvenile dermatomyositis – M Ganeva, S Stefanov
Scleroderma – K Temelkova, S Stefanov
Vasculitis – A Telcharova-Mihaylovska
Articular syndrome – S Stefanov, M Dikova
CHAPTER 10
Gastroenterology
Anatomical and physiological characteristics – P Yaneva
Major symptoms and signs of digestive tract disorders – P Yaneva
Oral cavity diseases – P Hadjiiski
Congenital anomalies
Diseases of oral soft tissues
Esophageal diseases – P Hadjiiski
Congenital anomalies
Gastroesophageal reflux disease
Eosinophilic esophagitis
Stomach diseases – P Hadjiiski
Congenital anomalies of the stomach
Pyloric atresia and membranous stenosis of the stomach
Acute gastritis
Ulcer
Intestinal diseases
Congenital anomalies – R Shentova-Eneva
Acute diarrhea – R Shentova-Eneva
Chronic diarrhea – P Yaneva
Celiac disease (gluten-sensitive enteropathy) – P Yaneva
Food allergy – P Yaneva
Inflammatory bowel diseases – R Shentova-Eneva
Pancreatic diseases – P Hadjiiski
Congenital anomalies
Acute pancreatitis
Chronic pancreatitis
Cystic fibrosis – M Baycheva
Anatomical and physiological characteristics of liver – M Baycheva
Liver diseases
Acute viral hepatitis – D Kofinova
Chronic hepatitis – P Yaneva
Autoimmune hepatitis – P Yaneva
Drug-induced liver injury – P Yaneva
Non-alcoholic fatty liver disease – D Kofinova
Neonatal cholestasis – M Baycheva
Metabolic diseases of the liver – M Baycheva
Cholelithiasis – P Hadjiiski
Liver cirrhosis – M Baycheva
CHAPTER 11
Pulmonology
Anatomy and physiology of the respiratory system in children – G Petrova
Methods of pulmonary examination – G Petrova, E Elencheva, P Perenovska
Main symptoms and syndromes
Respiratory failure – V Isaev
Cough in childhood – P Perenovska
Bronchial obstructive syndrome – S Mileva
Haemoptysis – G Petrova
Chest pain in childhood – H Shivatchev
Acute infections of the upper airways – M Yankova
Acute bronchiolitis – D Miteva, G Petrova, P Perenovska
Congenital anomalies of bronchopulmonary system – P Perenovska
Foreign bodies in the airways in children – P Perenovska
Bronchial asthma
Diagnosis of bronchial asthma in childhood – G Petrova
Management of acute asthma attack – V Isaev
Control of bronchial asthma in childhood – P Perenovska
Pneumonia in childhood – D Miteva, G Petrova, P Perenovska
Parapneumonic pleural complications – H Shivatchev
Spontaneous pneumotorax – H Shivatchev
Tuberculosis in childhood – S Velizarova
Bronchiectasis in childhood – P Perenovska
Cystic fibrosis – G Petrova
CHAPTER 12
Cardiology
Heart failure – A Dasheva-Dimitrova
Congenital heart diseases – A Dasheva-Dimitrova
Disturbances of cardiac rhythm and conduction – A Dasheva-Dimitrova
Inflammatory heart diseases – A Dasheva-Dimitrova
Cardiomyopathy – A Dasheva-Dimitrova
Arterial hypertension – N Kolarova-Yaneva, A Dasheva-Dimitrova
CHAPTER 13
Oncohematology
Benign blood diseases
Anemia
Anemia caused by inefficient red blood cell production – D Konstantinov
Iron-deficiency anemia
Other microcytic anemias
Anemia associated with hypoproteinemia
Anemia associated with folic acid and vitamin B12 deficiency
Congenital dyserythropoietic anemia
Hypoplastic and aplastic anemias – B Avramova, D Konstantinov
Congenital pancytopenia
Acquired aplastic anemia
Congenital erythroblastopenia
Marble bone disease
Hemolytic anemia – M Yordanova, D Konstantinov
Thalassemic syndromes – D Stoyanova, A Banchev
Hemoglobinopathies – A Banchev, D Stoyanova
Hereditary microspherocytosis
Other defects in the red cell membrane
Enzymopathies 271
Paroxysmal nocturnal hemoglobinuria
Microangiopathic haemolytic anemia
Neutropenia – B Avramova
Reactive changes in the white blood cell count
Bleeding disorders – A Banchev, D Stoyanova, D Konstantinov
Bleeding diathesis
Platelet disorders
Immune thrombocytopenia
Neonatal alloimmune thrombocytopenia
Neonatal autoimmune thrombocytopenia
Thrombocytopathies
Coagulopathies
Hemophilia A and B
Von Willebrand disease (VWD)
Deficiency of vitamin K-dependent factors
Thrombocytosis
Thrombophilia
Malignancies in childhood
Hematologic malignancies
Leukemia
Acute lymphoblastic leukemia – N Yurukova, D Konstantinov
Acute myeloid leukemia – K Bachvarov, D Konstantinov
Chronic leukemia – B Avramova
Lymphoma – I Vlahova, T Histova, B Avramova
Hodgkin lymphoma (Hodgkin disease)
Non-Hodgkin lymphoma (NHL)
Histiocytic syndromes – K Bachvarov
Solid malignant tumors290
Brain tumors – I Boronsuzov, I Shtarbanov
Neuroblastoma – I Boronsuzov I Shtarbanov
Nephroblastoma – I Chakarov, I Hristozova
Soft tissue sarcoma – I Boronsuzov, I Shtarbanov
Non-rhabdomyosarcoma soft tissue sarcomas – I Boronsuzov, I Shtarbanov
Ewing sarcoma – I Chakarov, I Hristozova
Osteogenic sarcoma – I Chakarov, I Hristozova
Hepatoblastoma – I Chakarov, I Hristozova
Retinoblastoma – I Chakarov, I Hristozova
Germ cell tumors – I Chakarov, I Hristozova 26
Rare tumors – I Boronsuzov I Shtarbanov
Hematopoietic stem cell transplantation – M Yordanova
Immunity – B Avramova, M Yordanova2
CHAPTER 14
Nephrology
Congenital anomalies of the kidneys and the urinary system – S Yankova Tzotcheva
Vesicoureteral reflux – S Yankova Tzotcheva
Urinary tract infections – S Yankova Tzotcheva
Nephritic syndrome – M Gaydarova
Rapidly progressive glomerulonephritis
IgA nephropathy
Membranoproliferative (mesangiocapillary) glomerulonephritis
Nephrotic syndrome – G Zlatanova-Rashkova
Membranous glomerulonephritis – G Zlatanova-Rashkova
Acute kidney injury – P Miteva-Choumnalieva, D Roussinov, K Dimitrova
Chronic kidney disease – P Miteva-Choumnalieva, D Roussinov, K Dimitrova
CHAPTER 15
Endocrinology
Pituitary diseases – E Stefanova
Thyroid diseases – D Iliev
Adrenal glands diseases – Z Todorova
Physiology and pathology of glucose metabolism – R Slavova, M Archinkova346
Hypoglycemia
Diabetes mellitus
Obesity – E Stefanova
Physiology and pathology of puberty – M Dimitrova
Calcium and phosphorus disorders – D Yordanova
CHAPTER 16
Neurology
Congenital anomalies of the central nervous system – M Bojidarova
Neurocutaneous syndromes (facomatosis) – M Bojidarova
Epilepsy in childhood
Definition, classification, types of seizures – G Tacheva
Diagnosis and treatment – G Tacheva
Epileptic syndromes
Idiopathic childhood epilepsy and syndromes – M Bojidarova, G Tacheva
Epileptic encephalopathy – I Litvinenko, D Stamatov
Febrile seizures – I Litvinenko, D Stamatov
Status epilepticus – I Litvinenko, D Stamatov
Cerebral palsy – I Litvinenko, G Tacheva
Neuromuscular diseases
Neuritis of the facial nerve – I Litvinenko, G Tacheva
Brachial plexus birth palsy – I Litvinenko, D Stamatov
Spinal muscular atrophy – I Litvinenko
Hereditary motor and sensory neuropathy – I Litvinenko
Primary muscle diseases – I Litvinenko
Myasthenia – I Litvinenko, D Stamatov
Ataxia – I Litvinenko
Guillain–Barré polyradiculoneuritis – I Litvinenko
Multiple sclerosis and demyelinating diseases in childhood – V Bojinova-Tchamova391
Headache in childhood – V Bojinova-Tchamova
CHAPTER 17
Coma in childhood – D Iliev
CHAPTER 18
Screening and screening programs – M Ivanova, I Stoeva
CHAPTER 19
Reference values of clinical laboratory parameters in children –
V Manolov, V Gancheva
COLORFUL APPLICATION